PHARMACEUTICALS AND PERSONAL CARE PRODUCTS IN THE ENVIRONMENT: POLLUTION FROM PERSONAL ACTIONS, ACTIVITIES, AND BEHAVIORS
PPCPs can enter the environment via excreta or wash water following their ingestion or application by users or their administration to domestic animals. Direct disposal of unused/expired PPCPs in landfills and domestic sewage is another route to the environment. Domestic sewage treatment plants are not specifically engineered to remove PPCPs; removal efficiencies vary from nearly complete to ineffective. The aquatic and groundwater environments serve as the major, ultimate receptacles for most PPCPs.
Little is known with respect to actual or even potential adverse effects on non-target species; human exposure via drinking water is even less understood. While PPCPs in the environment (or drinking water) are not regulated, and even though their concentrations are extremely low (ng/L-µg/L), the consequences of exposure over multiple generations to multitudes of compounds having different as well as similar modes of biochemical action prompts a plethora of questions. Although the environmental issues involved with two classes antibiotics (e.g., selection for pathogen resistance) and sex steroids (e.g., aromatase disruption in fish) are widely recognized, numerous other therapeutic and consumer-use classes of PPCPs pose a wide range of additional environmental concerns.
The occurrence of PPCPs in the environment is undoubtedly not a new phenomenon probably having taken place ever since any given PPCP first enjoyed commercial use. The U.S. EPA and other federal/state agencies are just beginning to consider the many scientific aspects of this wide-ranging topic.