THE CHARACTERISTICS OF CLAY MINERALS AFFECT CLAY-ANTIBIOTIC HYBRIDS : SMECTITE GROUP MINERALS AND AMINOGLYCOSIDE SERIES ANTIBIOTICS

Clay minerals are widely used to absorbent, carrier, excipient, and ingredient. Especially, as an absorbent and carrier, due to the huge amounts of cation exchange capacity (CEC) among natural materials it has been studied by mineralogists, pharmaceutical chemists, and material scientists. So, as a mineralogist in this study, I would like to reveal the characteristics of clay minerals-antibiotics hybrid controlled by properties of clay minerals. In this study, the samples are purchased as 2:1 type of clays which supplied by the clay minerals society and kunipia F. And two different bentonite samples from Pohang gampo in Korea are selected. Antibiotics are selected as clarithromycin (macrolide series), gentamicin, neomycin, and netilmicin (aminoglycoside series). The characteristics of clay minerals will be carried out by thermal-gravimetry (TG), scanning electron microscope – energy dispersive X-ray spectrometry (SEM-EDS), X-ray diffractometry (XRD), laser particle size analyzer, and experiment for CEC. The characteristics to know antibiotics-clay minerals hybrids are analyzed from adsorption kinetics by time in room temperature, maximum adsorption amount, theoretical behavior of antibiotics in interlayer of clays and release amount of antibiotics in hybrid. I expect that it is easier by this study to select the suits clay minerals for each usage and to explore the suit clay mineral deposits.